Adams, a tigerish presence in the middle of the park, was injured in the very early stages of the reverse fixture, the entertaining 4-4 draw at Old Trafford in December.
The 27-year-old missed a big chunk of the campaign as a result but returned to the fold for the draws against West Ham United, Sunderland and Brentford, picking up yellow cards in the latter two fixtures.
Julio Soler and Justin Kluivert also remain sidelined for the south-coast side.
United are without Lisandro Martinez, Matthijs de Ligt and Patrick Chinazaekpere Dorgu but Noussair Mazraoui could recover from illness, after missing training in midweek.